On August 27, 2026, the Jinfeng Interdisciplinary Academic Lecture (the third phase) was successfully held. The theme of this lecture is "Exploration of cognitive neural mechanisms and non-pharmacological intervention in the occurrence and development of depression". It focuses on three aspects: the neural mechanism of negative events affecting the development of depression, the brain mechanism of changes in depression's reward function, and the intervention of anhedonia. Professor Cao Bing from the Department of Psychology of Southwest University was specially invited to give a cutting-edge academic lecture.

Professor Cao Bing systematically elaborated on the cognitive neural mechanisms of depression and non-drug intervention strategies. In terms of the mechanism, childhood trauma and recent negative life events are important risk factors for adolescent depression. Inadequate adaptability and other factors constitute the key mediators connecting negative events and depression. Psychological resilience can weaken the direct and mediating effects of stress transforming into depression, indicating that adolescent depression is the result of the dynamic interaction of stress exposure, vulnerability and protective factors. At the cognitive neural level, the brain reward system plays a central role. Childhood trauma can reshape adolescent reward circuits, and abuse and neglect may create different neural patterns. Research on social reward and food reward paradigms has shown that depressed individuals have reduced reward sensitivity and weakened brain activation during the anticipation and feedback stages. When depression is combined with overweight or obesity, social reward processing impairment is exacerbated, accompanied by abnormal effective connections in areas such as the dorsomedial prefrontal lobe and insula. In terms of intervention, traditional CBT and imagery CBT can significantly reduce the depression level of adolescents with subthreshold depression, but have limited improvement in anhedonia. ； tDCS neuromodulation targeting the dorsomedial prefrontal lobe shows improvement potential.