Part one

1. Basic situation of the project

1. Project name: Research on the evolution prediction of the efficacy of neoadjuvant therapy for lung cancer and individualized decision-making methods based on longitudinal causal inference and dynamic treatment strategies. Service procurement

2. Project number: YY-FW-2026-D001

3. Project location: Chongqing-Guangdong Pathological Research Center

4. Procurement method: inquiry

2. Procurement content

3. Business requirements

1. Delivery time: Complete technical services within 240 days after signing the contract, submit all final delivery materials to the project and complete acceptance；

2. Service location: Chongqing-Guangdong Pathological Research Center, No. 313 Jinyue Road, Chongqing High-tech Zone；

3. Payment method: Within 120 days after the contract is signed, 50% of the fee will be paid after the project receives the phased results, and the remaining 50% will be paid after all final delivery materials are submitted and accepted by the project.

4. Total project price limit: The total quotation price shall not exceed the limit price of 195,000 yuan. The quoted price is a comprehensive lump sum price, including all equipment fees, software fees, installation fees, testing fees, travel expenses, freight, material fees, taxes, etc. The purchaser will not pay other fees separately.

4. Project requirements

Feedback on the implementation plan will be provided to the project within 5 working days after the contract takes effect, and project progress will be fed back every 2 weeks during the service period.； Submit phased results within 120 days after signing the contract, including at least the longitudinal variable system, causal structure hypothesis, preliminary confounding correction results, dynamic strategy modeling plan and mid-term experimental analysis conclusions ； Submit all final delivery materials before the expiration of the service period. The results should be able to actually support the writing, submission and revision of subsequent papers for this project, and form 1-2 paper results with the potential to be submitted to journals with an impact factor of 5 or above or journals with equivalent academic influence.

Technical requirement 1: Suppliers must construct a longitudinal causal structure diagram of the entire process of neoadjuvant treatment for lung cancer, and clarify the structural relationship between baseline variables, treatment intervention variables, time-varying covariates, mid-term efficacy indicators, pathological response outcomes and follow-up outcomes.

Technical requirement 2: Suppliers must carry out confounding factor correction and counterfactual efficacy estimation under observational clinical data, and compare at least two or more methods, including but not limited to propensity score, inverse probability weighting, double robust estimation, marginal structural model, structural nested model or target maximum likelihood estimation.

Technical requirement 3: Suppliers must establish a dynamic treatment strategy model, describe the sequential decision-making process of "initial treatment - mid-term evaluation - protocol adjustment - pathological response/prognostic outcome", and provide individual-level strategic value assessment and counterfactual strategy comparison.

Technical requirement 4: If the reinforcement learning method is used, it should be placed under the framework of causal inference and dynamic processing strategies, and the offline strategy evaluation, confounding correction, counterfactual risk control and uncertainty assessment mechanisms should be clearly defined. General Q-learning, DQN, PPO and other algorithm calls should not be used to replace clinical causal mechanism modeling.

Technical requirement 5: The final product should include model assumptions, causal identifiability conditions, estimator construction, error source analysis, sensitivity analysis and applicable boundary description. Project acceptance should not take single prediction accuracy as the only criterion, but should comprehensively examine causal rationality, statistical robustness, clinical interpretability and paper support.

5. Supplier qualification requirements

(1) Meet the qualifications of Article 22 of the "Government Procurement Law of the People's Republic of China":

1. Have the ability to independently bear civil liability；

2. Have good business reputation and sound financial accounting system；

3. Have the necessary equipment and professional technical capabilities to perform the contract；

4. Have a good record of paying taxes and social security funds in accordance with the law；

5. In the three years before participating in government procurement activities, there are no major illegal records in business activities.；

6. Other conditions stipulated by laws and administrative regulations.

Note: Paragraph 1 requires a business license, organization code certificate and tax registration certificate or public institution legal person certificate. If the three certificates are combined into one, only a business license is required.； Paragraphs 2-6 provide a declaration (see declaration for details).

6. Inquiry schedule

1. Inquiry release time: 12:00 on June 17, 2026

2. Inquiry deadline: 12:00 on June 25, 2026

Suppliers should send the quotation list and relevant attachments (which must be stamped with the official seal and scanned in color) to the contact email huna_na@163.com before the inquiry deadline. Those who do not quote before the inquiry deadline will be deemed to have automatically given up.

Supplier quotation documents should include the following attachments (see Part 2 for details):

(1) Quotation letter；

(2) Quotation list；

(3) Legal representative qualification certificate (if the bidder is an authorized representative, he must also provide a legal representative authorization letter)；

(4) Copy of business license or other organization certification documents；

(5) Statement；

(6) Letter of commitment.

7. Requirements for signature and sealing of quotation documents

1. The bidder should prepare a freshly stamped quotation document (PDF) and send it to the email address. The quotation document must be clearly visible, otherwise the quotation will be deemed invalid.

2. The quotation document should be produced in accordance with the requirements of the "Inquiry Announcement". The quotation document must be signed and sealed by the legal representative of the bidder or his authorized representative at the prescribed signature place. The signature, seal and content should be complete. If there are any omissions, you will bear the risk of being regarded as an invalid quotation.；

3. The quotation document should be written clearly and neatly. Any insertions, alterations, additions or deletions between the lines must be signed or stamped with a personal seal by the legal representative of the bidder or his authorized representative. Quotation documents that are illegible, unclearly expressed, or may lead to non-unique understanding will be deemed invalid.

Part 2.docx