Lecture time

May 21, 2026 (Thursday) 14:00-17:00

Lecture location

Conference Room 321, Building 1, Jinfeng Laboratory

Zang Guangchao , PhD, master's tutor, deputy director of Experimental Teaching Management Center of Chongqing Medical University； Associate Professor of Chongqing Medical University, Professor of the Second Clinical College of Chongqing Medical University (double appointment) ； Vice chairman of Chongqing Synthetic Biology Society, director of Chongqing Cognition Society, member of the Medical Device Professional Standing Committee of Chongqing Pharmaceutical Society, and IMed youth editorial board member. In the past five years, he has published nearly 40 papers as the corresponding author (including co-authors) in Science Bulletin, iMeta, Angewandte Chemie, Research, Bioactive Materials, Exprloration, Advanced Science, Biosensors and Bioelectronics, Chemical Engineering Journal, Small, etc., has 20 authorized patents, and drafted 4 team standards. Served as the person in charge of the "Biomedical Innovation and Entrepreneurship" micro major (Double Thousand Plan of the Ministry of Education). In the past five years, he has guided students to win nearly 100 awards at the provincial and ministerial level or above in the China International Internet+ Competition, Challenge Cup Competition, Life Science Competition and other Ministry of Education Class A competitions. ； Students were selected for honors such as the Self-improvement Star of Chinese College Students and the Chongqing Youth Science and Technology Innovation Mayor Award, and the training process was featured in CCTV Chinese International Channel.

Dynamic changes in key signals such as reactive oxygen species, neurotransmitters, and antioxidant molecules in the organ microenvironment are closely related to the occurrence and development of diseases, the evaluation of drug effects, and the construction of highly bionic organ chips. Focusing on this key scientific issue, the team focused on key biological signals in multiple organ systems such as the brain, liver, intestines and tumors, and developed a series of dynamic electrochemical analysis strategies. Relevant studies have focused on key biological signals such as changes in ascorbic acid during glutamate-induced brain cytotoxic edema, abnormal fluctuations of dopamine under neuroinflammation, redox imbalance in the tumor microenvironment, glutathione-mediated protective effects during hepatotoxicity, and 5-hydroxytryptamine release induced by mechanical stimulation of the intestinal mucosa. An electrochemical sensing detection system interface with high sensitivity, high selectivity, good anti-pollution ability, and flexible adaptation characteristics was constructed. The report will systematically summarize the interface design ideas and technical paths for in-situ, real-time, and dynamic detection of key biological signals in multi-organ microenvironments, and further explore the feasibility and application prospects of its integration with organ-on-a-chip platforms, with a view to providing reference for disease mechanism research, drug screening, and the construction of new smart organ-on-a-chip systems.