Book This lecture focused on the key scientific issue of how to use the mechanical environment within blood vessels to guide the design of biomaterials. The speaker pointed out that blood vessel wall cells can regulate their own proliferation, migration and differentiation through specific mechanical signal transduction pathways. However, existing vascular repair materials often ignore the mechanical-biological coupling process, resulting in poor mechanical adaptability between the material and the host tissue. In response to the above problems, the research team proposed a solution strategy based on the concept of mechanical adaptation: by constructing intelligent responsive biomaterials with mechanical properties that match vascular tissue, such as hydrogels and degradable scaffolds, they can regulate cell behavior in the dynamic mechanical environment in the body and promote in-situ regeneration of blood vessels. The lecture focused on the team’s specific ideas on material design. The results show that this strategy can significantly improve the mechanical compatibility between the implant and the host, providing new ideas and experimental basis for the development of a new generation of vascular repair materials. In addition, the lecture briefly introduced the scientific research layout of Jinfeng Laboratory and Chongqing University in this field, so that everyone can understand the relevant domestic research platforms and cooperation directions.

Book This lecture introduces surface modification strategies of engineered biomaterials to improve bone regeneration and antibacterial properties of orthopedic implants. The aging of the population has intensified the clinical demand for bone implants. However, traditional implant materials have the defects of biological inertness and no inherent antibacterial properties, which can easily lead to poor osseointegration and postoperative infection. To address these challenges, the lecture focused on surface modification methods using nanostructures and functional coatings. In particular, a ZnO-based nanostructure and ion-doped coating is introduced as an effective strategy to achieve dual functions, which can controlly release Zn²+, Ga³+ and Ag+ plasma, exert antibacterial effects through reactive oxygen species (ROS) generation, membrane destruction and metabolic interference, while promoting osteogenic differentiation and bone formation. Importantly, the lecture emphasized size-selective antibacterial strategies, which take advantage of the differences in size and structure between bacteria and mammalian cells to achieve bactericidal while retaining host cell compatibility. The lecture further emphasized that regulating surface chemistry, phase composition, and apatite layer formation can circumvent the bacterial shielding effect and create a microenvironment suitable for cell adhesion, proliferation, and tissue integration. In vivo experiments have confirmed that the modified surface can effectively resist infection, inhibit inflammation, promote bone regeneration and implant integration. These findings highlight the synergistic effects of nanostructure design, ion release, and surface engineering in improving implant performance, providing a comprehensive strategy for next-generation biomaterials that simultaneously address infection control and tissue regeneration.