Lecture time

November 25, 2025 15:00-16:00

Lecture location

Conference Room 502, Building 5, Jinfeng Laboratory

Lecture title: Research on the significance and mechanism of bone cell network reconstruction strategy in bone defect repair and treatment

Introduction to the speaker

Zhao Chen , Doctor of Medicine, deputy chief physician of joint surgery at the First Affiliated Hospital of Chongqing Medical University, scholar studying in the United States, member of the Shoulder and Elbow Sports Medicine Training Chongqing Center of the Chinese Medical Education Association, member of the Innovation and Transformation Group of the Orthopedics Branch of the Chongqing Medical Doctor Association, Chongqing Science and Technology Commissioner, and outstanding young talents of the First Affiliated Hospital of Chongqing Medical University. In recent years, he has published 13 SCI papers in Bone Research, Journal of Controlled Release, ACS Applied Materials & Interfaces, Stem Cell Research & Therapy and other journals, won 1 National Natural Science Foundation Youth Project, participated in 2 Natural Science Foundation General Projects, won 1 Chongqing Education Commission Project, and 1 National Postdoctoral Fellowship.

Lecture Introduction

In current bone regenerative medicine research, how to achieve "effective vascularization" has become a key challenge in repairing bone defects. In recent years, studies have found that osteocytes, as core regulators in bone, actively regulate angiogenesis through sophisticated signaling networks, providing a new perspective on bone repair. This lecture will focus on the core role of osteocytes in bone repair, focusing on: 1) Osteocytes recruit vascular endothelial cells through VEGF signaling ； 2) Its dendritic structure achieves spatiotemporal regulation of angiogenesis through the Notch pathway. ； 3) A new mechanism by which osteocytes-vascular units cooperate to promote functional bone regeneration. The revelation of this biological story provides a new theoretical basis and translational direction for promoting bone regeneration therapy.

Everyone is welcome to actively participate