Lecture time

November 19, 2025 10:00-11:00

Lecture location

Conference Room 302, Building 1, Jinfeng Laboratory

Lecture title: Glioma stem cell self-renewal mechanism and intervention strategies

Introduction to the speaker

Wang Xiuxing , professor, doctor, doctoral supervisor； Winner of the National Natural Science Foundation of China Youth Science Fund Category A (formerly the National Science Fund for Distinguished Young Scholars), national-level overseas high-level young talent, and Distinguished Professor of Jiangsu Province ； Executive director of the Neuro-Oncology Branch of the Chinese Society of Neuroscience, member of the Tumor Cell Biology Branch of the Chinese Society of Cell Biology, standing member of the Hypoxic Oncology Committee of the Chinese Anti-Cancer Association, member of the Tumor Rhythm Special Committee of the Chinese Anti-Cancer Association, member of the Medical Cell Biology Branch of the Chinese Society of Cell Biology, and Basic and Transformation Committee of the Glioma Professional Committee of the Chinese Medical Doctor Association. ； Professor at the Department of Cell Biology, School of Basic Medicine, Nanjing Medical University/Key Laboratory of Antibody Technology, National Health Commission.

Lecture Introduction

Glioblastoma (GBM) is a highly malignant central nervous system tumor. The postoperative recurrence rate of GBM patients is as high as more than 90%, and the five-year survival rate in pan-cancer is extremely low, which has long been a major clinical problem. Currently, there is no effective treatment for GBM, and cutting-edge treatments such as immunotherapy and targeted therapy are very limited in improving the prognosis of patients. Glioblastoma stem cells cell (GSC) and the complex tumor microenvironment around it are the key factors that cause GBM to be highly malignant and for which there is no effective treatment. GSC and its immune microenvironment jointly lead to immune escape, treatment resistance and recurrence of GBM. This lecture will focus on the key scientific issue of "glioma stem cell self-renewal mechanism and intervention strategy", taking GSC and its immune microenvironment as a whole research, revealing the new components of the immune microenvironment and the mechanism of GSC itself to maintain GSC self-renewal in an all-round and multi-angle manner, as well as the self-renewing GSC. Reversely reshape the immune microenvironment mechanism to provide theoretical basis and targets for new strategies for GBM treatment.

Everyone is welcome to actively participate