Lecture time

April 22, 2025 (Tuesday) 9:30-12:00

Lecture location

Conference Room 809, Building 1, Jinfeng Laboratory

Lecture topic

Improving therapeutics access to tumors through engineered endothelial leakiness

Introduction to the speaker

Professor David Tai Wei Leong, Deputy Director of Scientific Research, Department of Chemistry and Biomolecular Engineering, National University of Singapore, PhD Supervisor, and Fellow of the Royal Chemistry Society of England. He serves as the Associate Editor of Bioactive Materials (IF 18.9), Science and Technology of Advanced Materials (lF 5.5), and Nanolmpact (lF 4.9). More than 170 SCl papers have been published in journals such as Nature Nanotechnology, Nature Communications, Advanced Science, Biomaterials, etc., with more than 18,000 citations, and H factor 70.

Lecture summary

Although most cancer nanomedicines are designed to eliminate cancer, the nanomaterial itself can lead to the formation of micron-scale slits in the endothelial walls of the blood vessels. Nanomaterial-induced endothelial cell leakage (NanoEL) may help in infiltrate surviving cancer cells into the surrounding vasculature and subsequently exudate, thereby accelerating metastasis. Nanoparticles induce endothelial penetration by disrupting the homogeneous interaction of VE-cadherin-VE-cadherin at the adhesion junction. Some nanomaterials can induce pores between endothelial cells, among which the three important parameters that determine the extent of vascular endothelial leakage induces nanomaterials are the size, density and surface charge of nanoparticles. Professor Leong's team used the NanoEL effect to improve the ability of drugs and nanoformula into tumors, improving treatment effects while avoiding side effects. The application of NanoEL will help people better utilize the powerful tool of nanomaterials, providing a new way to tumor treatment and bringing more possibilities to people's lives.

Everyone is welcome to actively participate