Lecture time

April 10, 2025 (Thursday)                    16:00-18:00

Lecture location

Conference Room 426, Building 4, Jinfeng Laboratory

Lecture topic

Study on overcoming drug resistance of photocontrol activated anti-tumor prodrug based on clinical platinum drugs

Introduction to the speaker

Deng Zhiqin，Professor, doctoral supervisor, Hongshen outstanding scholar, was selected for the national youth talent program. Mainly engaged in the research and development and mechanism research of new anti-tumor drugs, especially metal anti-tumor drugs. As the first author (including co-) he published 14 papers in journals such as Nature Chemistry, Nature Catalysis, Nature Synthesis, JACS, Biomaterials, etc., and won the 2023 Hong Kong Youth Scientist Award, the Chinese Chemistry Association Jingqing Chemistry Spark Award and other awards. He presided over the National Natural Science Foundation of China, Chongqing Overseas Talent Attraction Project, Chongqing Natural Science Foundation of China and other projects.

Lecture summary

Platinum drugs are one of the most widely used anti-tumor drugs in clinical practice, and drug resistance and major toxic side effects are the key bottlenecks that restrict their therapeutic effect. The development of photoactivated platinum-like prodrugs can achieve precise activation of clinical platinum drugs in tumor sites through photo-controlled spatiotemporal specific activation strategies, improve anti-tumor effects and reduce systemic toxicity. In the future, through further functional design of photo-activated platinum prodrug, it is expected to achieve the combination of multiple therapies such as photo-switch control chemotherapy-immunotherapy, and further enhance the anti-tumor effect.