lecture title

Modeling and targeting glioblastoma:

from mouse to human

introduction to the keynote speakers

professor liu haikun, director of the department of molecular neurogenetics at the german cancer research center, distinguished professor at the institute of immunochemistry, shanghaitech university, and has received multiple awards and funding, including the embo young scientist program (the only chinese winner in 15 years), dkfz international scientist award and european research council erc consolidator fund, etc.

key points of the lecture

glioblastoma (gbm) is an often fatal disease with limited treatments. extracting information with mechanistic insights and therapeutic effects from complex multidimensional data sets remains a significant challenge.

the laboratory of professor liu haikun's team used independently established mouse models of human brain cancer to conduct in-depth research on the molecular mechanisms of neural stem cells (nscs) and brain tumor stem cells (btscs) in the occurrence of brain cancer. with precision cancer medicine as the core concept, professor liu haikun described in detail the basic developmental principles of tumor growth. his research results not only provide new insights into cancer development, but also provide new insights into tumor heterogeneity and glioblastoma (gbm) treatment. it provides a new direction and supports further research on tumor initiation, genetic evolution and preclinical target validation in primary tumor models.

professor liu haikun's team further studied key molecules and cells related to tumor occurrence and development, discovered molecular markers related to early and accurate diagnosis of brain cancer, and screened out precise diagnosis and treatment targets targeting the tumor microenvironment and heterogeneity to reveal tumor progression. the important mechanism provides an effective solution for the personalized prevention and treatment of brain cancer.